Parkinson's Disease

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Parkinson’s disease is a slowly progressive, chronic neurological condition that causes a gradual loss of dopamine-producing neurons within the Substantia Nigra.  this region of the midbrain controls movement and coordination.  Therefore, decreased dopamine levels lead to uncontrollable movements, such as shaking, stiffness, and difficulty with balance and coordination.

Signs and Symptoms include: 

• Resting Tremor: Rhythmic shaking may decrease when performing tasks (Intention Tremor). 
• Pill-Rolling Tremor: Rubbing of thumb and forefinger.
• Bradykinesia: Slowed movements, dragging or shuffling feet when walking, and difficulty getting out of chair. 
• Muscle Rigidity: Limited range of motion. 
• Impaired balance
• Changes in Speech 
• Behavioral or mood changes
• Dementia
• Insomnia

References: 

1.   Evidence for the use of cannabinoids in Parkinson's disease

2.  An overview of Parkinson's disease and the cannabinoid system and possible benefits of cannabinoid-based treatments

3.  Potential role of cannabinoids in Parkinson's disease

4.  Cannabinoid receptor as a potential therapeutic target for Parkinson's Disease

5.  Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection